Endocrine Abstracts

It is well known that weight losses in the range of 2.5–5% are able to improve factors of the metabolic syndrome such as insulin sensitivity. Several studies have been published concerning weight loss and subsequent changes in inflammatory markers and indicate that higher weight losses are necessary to affect the inflammatory markers than are needed to affect insulin sensitivity. Some data showed impairment of insulin sensitivity in diabetic patients during starvation. Th...

C-reactive protein (CRP) is closely associated with obesity and cardiovascular disease in both diabetic and nondiabetic subjects. The aim of our study was to investigate the effects of commonly prescribed antidiabetic agent metformin on CRP and insulin sensitivity in type 2 diabetes patients after 12 weeks of therapy. Twenty-three newly diagnosed type 2 diabetic patients (mean age: 49.74±2.03 years; mean BMI: 31.40±1.27 kg/m2) have been given metformin 2 g...

It has been shown that low values of insulin sensitivity have been related to metabolic diseases. Exercise prescription is crucial to prevent low insulin sensitivity in general population, and athletes are good physiological model. If this assumption is correct, examine insulin sensitivity in elite athletes should reflect the positive effect of exercise on insulin sensitivity. The aim of this study was to investigate the effects of regular exercise on insulin sensitivity estim...

Balance between pro- and anti- inflammatory cytokines is necessary for the physiological functioning of the immune system. A chronic systemic inflammation is one of the causes of insulin resistance in obesity.The aim of this study was to investigate the pro-inflammatory cytokines and visfatin response to an single bout acute exercise in athletes and non-athletes, as well as the possible relationship pro-inflammatory cytokines with body composition and in...

The aim of this study was to investigate adipocytokine responses to an single bout acute exercise in elite athletes with a low percentage of body fat, elite athletes with a high percentage of body fat and sedentary controls. Sixteen athletes with low percentage of body fat (volleyball players, low fat athletes group, LFAG), 15 athletes with high percentage of body fat (the elite water polo players, high fat athletes group, HFAG) and 15 sedentary subjects participated in this s...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare multitumour syndrome, characterized by the occurrence of parathyroid (PHPT), pituitary adenoma (PA) and pancreatic neuroendocrine tumors (pNETs). The gene responsible is MEN1 gene, however 10 to 20% of patients are not carriers of MEN1 mutation. Recently, a study has shown that these patients have less aggressive course of the disease, and more favorable life expectancy than their mutation-pos...